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          溶瘤病毒/DC-CIK技術平臺
           

          將已構建的插入IL-24等細胞因子編碼基因的溶瘤病毒,轉染到體外誘導的CIK細胞內,通過特殊的基因改造,使溶瘤病毒在CIK細胞內增殖但不破壞CIK細胞,然后向患者體內回輸CIK細胞,使融瘤病毒特異性導向腫瘤細胞,在其內大量復制并*終摧毀腫瘤細胞。


          技術特點

          l   CIK細胞本身具有非MHC限制性的非特異性免疫殺傷作用,對腫瘤細胞有殺傷活性;

          l   通過CIK細胞攜帶溶瘤病毒并釋放到腫瘤細胞內,使溶瘤病毒特異性導向腫瘤細胞,并發揮溶瘤活性;

          l   插入在溶瘤病毒基因組的細胞因子基因隨著病毒的擴增在腫瘤細胞內表達,并釋放細胞因子,直接發揮抗腫瘤活性;

          l   CIK細胞作為載體向腫瘤細胞導向溶瘤病毒,減少溶瘤病毒直接注射被機體免疫系統的清除以及副作用;


              因此這種溶瘤病毒與CIK免疫細胞的聯合治療法比單一的細胞治療或溶瘤病毒治療具有更高的特異性和殺傷活性。


          Oncolytic virus / CIK technology


          The oncolytic virus integrated with IL-24 and other cytokine genes was transduced into CIK cells. The genetically modified oncolytic virus would proliferate in CIK cells without destroying CIK cells. The virus harbored CIK cells were then transfused to the patient, specifically targeting the oncolytic virus to tumor cells, and ultimately destroy the tumor cells.

           

          Technical features

          1.   CIK cells possess non-MHC-specific and nonspecific cytotoxicity against tumor cells;

          2.   Oncolytic virus carried in the CIK cells would be targeted to, released into and then more

                efficiently kill the tumor cells;

          3.   The cytokine gene integrated in the genome of the oncolytic virus is expressed in the tumor

                cells along with the expansion of the virus, which directly develop the antitumor activity.

          4.   Using CIK cell as carrier of oncolytic virus helps to reduce the clearence of virus by receptor

                immune system and otherwise some side effects caused by naked virus injection

          Therefore, the combination of the oncolytic virus and CIK immune cells has a higher specificity and killing activity than CIK or oncolytic virus alone.



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