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          • 公司地址: 上海普陀區中江路879弄4號樓B座3層
            電話: 021-51621262
            地鐵線路: 13號線大渡河路站4號口
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          雙特異性抗體/DC-CIK技術平臺
           

          雙特異性抗體是含有兩種特異性抗原結合位點的雙功能抗體。我們通過化學交聯法將抗CD3單抗與曲妥珠單抗交聯,獲得了對腫瘤細胞和淋巴細胞的雙向識別作用的雙特異抗體。此雙特異性抗體一方面通過CD3單抗識別CIK細胞;另一方面,通過曲妥珠單抗識別腫瘤表面HER2受體。


          在DC-CIK細胞體外誘導、培養的**階段加入該雙特異抗體,雙特異抗體即通過抗CD3抗體結合到CIK細胞表面,CIK細胞回輸到體內后,其表面的雙特異抗體將CIK細胞靶向募集到腫瘤細胞表面,從而提高CIK細胞對腫瘤細胞的識別和殺傷活性。


          技術特點

          l   制備技術相對簡單;

          l   利用抗體-抗原的強大親和力,大大提高DC-CIK細胞對腫瘤細胞的識別和殺傷機會。



          Bispecific antibody / DC-CIK technology

          A bispecific antibody is a bifunctional antibody that contains two specific antigen binding sites. We cross-linked anti-CD3 monoclonal antibody with trastuzumab by chemical cross-linking, and obtained bi-specific antibodies for bi-directional recognition of tumor cells and lymphocytes. This bispecific antibody recognizes CIK cells via CD3 target and recognizes tumor cells via HER2 receptor.

          In the final stage of DC-CIK cells culturing, the bispecific antibody was added and binds to the surface of CIK cells through anti-CD3 antibody. After transfusion, the  cells were recruited to tumor cells through bispecific antibody, thereby enhancing the recognition and killing activity of CIK cells to tumor cells.

           

          Technical features

          1.   The preparation technique is relatively simple

          2.   The strong affinity of antibody to antigen greatly improves the DC-CIK cells on tumor

                cell recognition and killing opportunities



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