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          双特异性抗体/HIM-IC技术平台
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          双特异性抗体是含有两种特异性抗原结合位点的双功能抗体。我

          们通过化学交联法将抗CD3单抗与曲妥珠单抗交联,获得了对肿瘤

          细胞和淋巴细胞的双向识别作用的双特异抗体。此双特异性抗体

          方面通过CD3单抗识别HIM-IC细胞;另一方面,通过曲妥珠单抗识

          别肿瘤表面HER2受体。


          在HIM-IC细胞体外诱导、培养的*后阶段加入该双特异抗体,双特

          异抗体即通过抗CD3抗体结合到HIM-IC细胞表面,HIM-IC细胞回输到体内

          后,其表面的双特异抗体将HIM-IC细胞靶向募集到肿瘤细胞表面

          而提高HIM-IC细胞对肿瘤细胞的识别和杀伤活性。


          技术特点

          l?? 制备技术相对简单;

          l? ?利用抗体-抗原的强大亲和力,大大提高HIM-IC细胞对肿瘤细胞

          识别和杀伤机会。



          Bispecific antibody / DC-CIK technology

          A bispecific antibody is a bifunctional antibody that contains two specific antigen?

          binding sites. We cross-linked anti-CD3 monoclonal antibody with trastuzumab

          ?by chemical cross-linking, and obtained bi-specific antibodies for bi-directional?

          recognition of tumor cells and lymphocytes. This bispecific antibody recognizes

          ?CIK cells via CD3 target and recognizes tumor cells via HER2 receptor.

          In the final stage of DC-CIK cells culturing, the bispecific antibody was added and

          ?binds to the surface of CIK cells?through anti-CD3 antibody. After transfusion,?the?

          ?cells were recruited to tumor cells through bispecific antibody, thereby enhancing

          ?the recognition and killing activity of CIK cells to tumor cells.

          ?

          Technical features

          1.?? The preparation technique is relatively simple

          2.?? The strong affinity of antibody to antigen greatly improves the DC-CIK cells on

          ?tumorcell recognition and killing opportunities



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