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          CAR-T细胞治疗技术平台
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          嵌合抗原受体T细胞(CAR-T细胞)是在体外构建一个嵌合

          基因,包括识别肿瘤抗原的单链抗体可变区的基因片段和

          T细胞激活辅助因子的基因片段,然后通过转导的方法转染

          患者的T细胞,即“重编码”患者的T细胞,使其表达嵌合

          抗原受体(CAR)。经体外培养生成大量肿瘤特异性的CAR-T

          细胞,回输到患者体内,达到有效识别和杀伤肿瘤细胞的

          目的。


          技术特点

          l? 靶点不受MHC的限制;

          l? 识别靶分子的亲和力强,有效捕捉癌细胞;

          l? 可设计成多靶点的CAR基因,减少或者消除细胞因子释放

          症的副作用;

          l? 具有免疫记忆功能。


          CAR-T?Technology

          ????Chimeric antigen receptors?T cells (CAR-T) designates the technology

          ?that engineers receptors (usually single chain monoclonal antibody plus

          ?the sequence of T cell costimulatory domains) and expresses them on??

          T cells. Thus constructed CAR-T cells specifically recognize and kill

          ?tumor cells, as demonstrated in vitro and in vivo.

          Technical features

          1.????Targets are not restrained by MHC, broad-spectrum indications

          2.????Strong affinity to the target molecules on cancer cells, efficient

          ?killing?of cancer cells in? culture or in?circulating system;

          3.????can be designed to multiple target points and more accurate, to?

          reduce side effects of?cytokine release

          4.????With immune memory function



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